His films combine documentary with fiction, often inspired by autobiographical experiences and observations of everyday life. In 2009, he represented Romania at the Venice Biennale, in the exhibition The Seductiveness of the Interval, with the films Trolleybus 92-an analysis of everyday psychological violence-and Passagen, a documentary about Pedro Garretón Ramirez's experiences after the coup in Chile (1973). The installation, conceived with a theatrical structure, later toured in 2010 at The Renaissance Society in Chicago.

Among his major film projects are Family Dinner (2012), a film about subtle family tensions, selected in the "Semaine de la Critique" competition at Cannes; 6 Big Fish (2015), a visual reflection on destiny and freedom, presented at Locarno in the "Pardi di domani" section; and his feature film debut, Man and Dog (2022), premiered at the Göteborg Film Festival and subsequently screened at numerous international festivals. Constantinescu continues to work at the intersection of film and visual arts, developing projects that interrogate how recent history shapes contemporary identities. He is currently working on Vermilion, a science fiction film.